Chitosan microbeads for encapsulation of thyme (Thymus serpyllum L.) polyphenols
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2014
Authors
Trifković, Kata T.Milašinović, Nikola
Đorđević, Verica B.
Kalagasidis-Krušić, Melina T.
Knežević-Jugović, Zorica
Nedović, Viktor
Bugarski, Branko M.
Article (Published version)
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In this work chitosan microbeads were prepared by emulsion technique and loaded with thyme polyphenols by diffusion from an external aqueous solution of Thymus serpyllum L. The effects of concentrations of chitosan (1.5-3% (w/v)) and GA (glutaraldehyde) (0.1-0.4% (v/v)), as a crosslinking agent on the main properties of microbeads were assessed. The obtained microgel beads from similar to 220 to similar to 790 mu m in diameter were exposed to controlled drying process at air (at 37 degrees C) after which they contracted to irregular shapes (similar to 70-230 mu m). The loading of dried microbeads with polyphenols was achieved by swelling in the acidic medium. The swelling rate of microbeads decreased with the increase in GA concentration. Upon this rehydration, thyme polypheriols were effectively encapsulated (active load of 66-114mg GAEg(beads)(-1)) and the microbeads recovered a spherical shape. Both, the increase in the amount of the crosslinking agent and the presence of polyphenol...s, contributed to a more pronounced surface roughness of microbeads. The release of encapsulated polyphenols in simulated gastrointestinal fluids was prolonged to 3 h.
Keywords:
Emulsion crosslinking technique / Chitosan microbeads / Polyphenols / MicroencapsulationSource:
Carbohydrate polymers, 2014, 111, 901-907Publisher:
- Elsevier Sci Ltd, Oxford
Funding / projects:
- Novel encapsulation and enzyme technologies for designing of new biocatalysts and biologically active compounds targeting enhancement of food quality, safety and competitiveness (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-46010)
- Synthesis and characterization of novel functional polymers and polymeric nanocomposites (RS-MESTD-Basic Research (BR or ON)-172062)
DOI: 10.1016/j.carbpol.2014.05.053
ISSN: 0144-8617
WoS: 000340302100109
Scopus: 2-s2.0-84902330332
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JakovTY - JOUR AU - Trifković, Kata T. AU - Milašinović, Nikola AU - Đorđević, Verica B. AU - Kalagasidis-Krušić, Melina T. AU - Knežević-Jugović, Zorica AU - Nedović, Viktor AU - Bugarski, Branko M. PY - 2014 UR - http://jakov.kpu.edu.rs/handle/123456789/577 AB - In this work chitosan microbeads were prepared by emulsion technique and loaded with thyme polyphenols by diffusion from an external aqueous solution of Thymus serpyllum L. The effects of concentrations of chitosan (1.5-3% (w/v)) and GA (glutaraldehyde) (0.1-0.4% (v/v)), as a crosslinking agent on the main properties of microbeads were assessed. The obtained microgel beads from similar to 220 to similar to 790 mu m in diameter were exposed to controlled drying process at air (at 37 degrees C) after which they contracted to irregular shapes (similar to 70-230 mu m). The loading of dried microbeads with polyphenols was achieved by swelling in the acidic medium. The swelling rate of microbeads decreased with the increase in GA concentration. Upon this rehydration, thyme polypheriols were effectively encapsulated (active load of 66-114mg GAEg(beads)(-1)) and the microbeads recovered a spherical shape. Both, the increase in the amount of the crosslinking agent and the presence of polyphenols, contributed to a more pronounced surface roughness of microbeads. The release of encapsulated polyphenols in simulated gastrointestinal fluids was prolonged to 3 h. PB - Elsevier Sci Ltd, Oxford T2 - Carbohydrate polymers T1 - Chitosan microbeads for encapsulation of thyme (Thymus serpyllum L.) polyphenols VL - 111 SP - 901 EP - 907 DO - 10.1016/j.carbpol.2014.05.053 ER -
@article{ author = "Trifković, Kata T. and Milašinović, Nikola and Đorđević, Verica B. and Kalagasidis-Krušić, Melina T. and Knežević-Jugović, Zorica and Nedović, Viktor and Bugarski, Branko M.", year = "2014", abstract = "In this work chitosan microbeads were prepared by emulsion technique and loaded with thyme polyphenols by diffusion from an external aqueous solution of Thymus serpyllum L. The effects of concentrations of chitosan (1.5-3% (w/v)) and GA (glutaraldehyde) (0.1-0.4% (v/v)), as a crosslinking agent on the main properties of microbeads were assessed. The obtained microgel beads from similar to 220 to similar to 790 mu m in diameter were exposed to controlled drying process at air (at 37 degrees C) after which they contracted to irregular shapes (similar to 70-230 mu m). The loading of dried microbeads with polyphenols was achieved by swelling in the acidic medium. The swelling rate of microbeads decreased with the increase in GA concentration. Upon this rehydration, thyme polypheriols were effectively encapsulated (active load of 66-114mg GAEg(beads)(-1)) and the microbeads recovered a spherical shape. Both, the increase in the amount of the crosslinking agent and the presence of polyphenols, contributed to a more pronounced surface roughness of microbeads. The release of encapsulated polyphenols in simulated gastrointestinal fluids was prolonged to 3 h.", publisher = "Elsevier Sci Ltd, Oxford", journal = "Carbohydrate polymers", title = "Chitosan microbeads for encapsulation of thyme (Thymus serpyllum L.) polyphenols", volume = "111", pages = "901-907", doi = "10.1016/j.carbpol.2014.05.053" }
Trifković, K. T., Milašinović, N., Đorđević, V. B., Kalagasidis-Krušić, M. T., Knežević-Jugović, Z., Nedović, V.,& Bugarski, B. M.. (2014). Chitosan microbeads for encapsulation of thyme (Thymus serpyllum L.) polyphenols. in Carbohydrate polymers Elsevier Sci Ltd, Oxford., 111, 901-907. https://doi.org/10.1016/j.carbpol.2014.05.053
Trifković KT, Milašinović N, Đorđević VB, Kalagasidis-Krušić MT, Knežević-Jugović Z, Nedović V, Bugarski BM. Chitosan microbeads for encapsulation of thyme (Thymus serpyllum L.) polyphenols. in Carbohydrate polymers. 2014;111:901-907. doi:10.1016/j.carbpol.2014.05.053 .
Trifković, Kata T., Milašinović, Nikola, Đorđević, Verica B., Kalagasidis-Krušić, Melina T., Knežević-Jugović, Zorica, Nedović, Viktor, Bugarski, Branko M., "Chitosan microbeads for encapsulation of thyme (Thymus serpyllum L.) polyphenols" in Carbohydrate polymers, 111 (2014):901-907, https://doi.org/10.1016/j.carbpol.2014.05.053 . .