TY  - JOUR
AU  - Vidović, Bojana
AU  - Milašinović, Nikola
AU  - Kotur-Stevuljević, Jelena
AU  - Dilber, Sanda P.
AU  - Kalagasidis-Krušić, Melina T.
AU  - Đoržević, Brižita
AU  - Knežević-Jugović, Zorica
PY  - 2016
UR  - http://jakov.kpu.edu.rs/handle/123456789/732
AB  - Alpha-lipoic acid is an organosulphur compound well-known for its therapeutic potential and antioxidant properties. However, the effective use of alpha-lipoic acid depends on biological plasma half-life and its preserving stability, which could be improved by encapsulation. In this study, alpha-lipoic acid was incorporated into chitosan microparticles obtained by reverse emulsion crosslinking technique, as well as into microparticles of alginate/gelatin crosslinked with zinc ions. Encapsulation of alpha-lipoic acid in both cases was carried out by swelling of synthesized dried microparticles by their dipping in a solution of the active substance under strictly controlled conditions. Encapsulation efficiency of alpha-lipoic acid obtained in this study was up to 53.9%. The structural interaction of alpha-lipoic acid with the carriers was revealed by Fourier transform infrared spectroscopy. In vitro released studies showed that controlled release of alpha-lipoic acid was achieved through its encapsulation into chitosan microparticles. The results of in vitro antioxidative activity assays of released alpha-lipoic acid indicated that antioxidant activity was preserved at a satisfactory level. These obtained results suggested that chitosan microparticles could be suitable for modeling the controlled release of alpha-lipoic acid.
PB  - Association of Chemical Engineers of Serbia
T2  - Hemijska industrija
T1  - Encapsulation of alpha-lipoic acid into chitosan and alginate/gelatin hydrogel microparticles and its in vitro antioxidant activity
VL  - 70
IS  - 1
SP  - 49
EP  - 58
DO  - 10.2298/HEMIND141119010V
ER  - 

@article{
author = "Vidović, Bojana and Milašinović, Nikola and Kotur-Stevuljević, Jelena and Dilber, Sanda P. and Kalagasidis-Krušić, Melina T. and Đoržević, Brižita and Knežević-Jugović, Zorica",
year = "2016",
abstract = "Alpha-lipoic acid is an organosulphur compound well-known for its therapeutic potential and antioxidant properties. However, the effective use of alpha-lipoic acid depends on biological plasma half-life and its preserving stability, which could be improved by encapsulation. In this study, alpha-lipoic acid was incorporated into chitosan microparticles obtained by reverse emulsion crosslinking technique, as well as into microparticles of alginate/gelatin crosslinked with zinc ions. Encapsulation of alpha-lipoic acid in both cases was carried out by swelling of synthesized dried microparticles by their dipping in a solution of the active substance under strictly controlled conditions. Encapsulation efficiency of alpha-lipoic acid obtained in this study was up to 53.9%. The structural interaction of alpha-lipoic acid with the carriers was revealed by Fourier transform infrared spectroscopy. In vitro released studies showed that controlled release of alpha-lipoic acid was achieved through its encapsulation into chitosan microparticles. The results of in vitro antioxidative activity assays of released alpha-lipoic acid indicated that antioxidant activity was preserved at a satisfactory level. These obtained results suggested that chitosan microparticles could be suitable for modeling the controlled release of alpha-lipoic acid.",
publisher = "Association of Chemical Engineers of Serbia",
journal = "Hemijska industrija",
title = "Encapsulation of alpha-lipoic acid into chitosan and alginate/gelatin hydrogel microparticles and its in vitro antioxidant activity",
volume = "70",
number = "1",
pages = "49-58",
doi = "10.2298/HEMIND141119010V"
}

Vidović, B., Milašinović, N., Kotur-Stevuljević, J., Dilber, S. P., Kalagasidis-Krušić, M. T., Đoržević, B.,& Knežević-Jugović, Z.. (2016). Encapsulation of alpha-lipoic acid into chitosan and alginate/gelatin hydrogel microparticles and its in vitro antioxidant activity. in Hemijska industrija
Association of Chemical Engineers of Serbia., 70(1), 49-58.
https://doi.org/10.2298/HEMIND141119010V

Vidović B, Milašinović N, Kotur-Stevuljević J, Dilber SP, Kalagasidis-Krušić MT, Đoržević B, Knežević-Jugović Z. Encapsulation of alpha-lipoic acid into chitosan and alginate/gelatin hydrogel microparticles and its in vitro antioxidant activity. in Hemijska industrija. 2016;70(1):49-58.
doi:10.2298/HEMIND141119010V .

Vidović, Bojana, Milašinović, Nikola, Kotur-Stevuljević, Jelena, Dilber, Sanda P., Kalagasidis-Krušić, Melina T., Đoržević, Brižita, Knežević-Jugović, Zorica, "Encapsulation of alpha-lipoic acid into chitosan and alginate/gelatin hydrogel microparticles and its in vitro antioxidant activity" in Hemijska industrija, 70, no. 1 (2016):49-58,
https://doi.org/10.2298/HEMIND141119010V . .

TY  - JOUR
AU  - Dopsaj, Violeta
AU  - Martinović, Jelena
AU  - Dopsaj, Milivoj
AU  - Kasum, Goran
AU  - Kotur-Stevuljević, Jelena
AU  - Koropanovski, Nenad
PY  - 2013
UR  - http://jakov.kpu.edu.rs/handle/123456789/512
AB  - The aim of this study was to profile hematological, oxidative stress, and immunological parameters in male athletes who practiced combat sports and to determine whether the type of combat sport influenced the measured parameters. Eighteen karate professionals, 15 wrestlers, and 14 kickboxers participated in the study. Hematological, iron-related, oxidative stress, and immunological parameters were measured at the beginning of a precompetitive period. The general linear model showed significant differences between the karate professionals, wrestlers, and kickboxers with respect to their hematological and iron status parameters (Wilks' Lambda = 0.270, F = 2.186, p  lt  0.05) and oxidative stress status (Wilks' Lambda = 0.529, F = 1.940, p  lt  0.05). The immature reticulocyte fraction was significantly higher in wrestlers (0.30 +/- 0.03) compared with kickboxers (0.24 +/- 0.04; p  lt  0.05) and karate professionals (0.26 +/- 0.04; p  lt  0.05). Low hemoglobin density was significantly lower in wrestlers and kickboxers (p  lt  0.05) compared with karate professionals (karate: 3.51 +/- 1.19, wrestlers: 1.95 +/- 1.10, and kickboxers: 1.77 +/- 0.76). Significant differences were observed between the karate professionals and wrestlers with respect to their pro-oxidant-antioxidant balance (437 +/- 103 vs. 323 +/- 148, p  lt  0.05) and superoxide-dismutase activity (SOD) (73 +/- 37 vs. 103 +/- 30, p  lt  0.05). All the measured parameters (with the exception of SOD activity) fell within their physiological ranges, indicating that the study participants represented a young and healthy male population. Hematological parameters differed between kickboxers and karate professionals. The low pro-oxidant-antioxidant balance and high SOD activity in wrestlers could be associated with the long-term impact of wrestling as a type of strenuous exercise.
PB  - Lippincott Williams & Wilkins, Philadelphia
T2  - Journal of strength and conditioning research
T1  - Hematological, oxidative stress, and immune status profiling in elite combat sport athletes
VL  - 27
IS  - 12
SP  - 3506
EP  - 3514
DO  - 10.1519/JSC.0b013e31828ddeea
ER  - 

@article{
author = "Dopsaj, Violeta and Martinović, Jelena and Dopsaj, Milivoj and Kasum, Goran and Kotur-Stevuljević, Jelena and Koropanovski, Nenad",
year = "2013",
abstract = "The aim of this study was to profile hematological, oxidative stress, and immunological parameters in male athletes who practiced combat sports and to determine whether the type of combat sport influenced the measured parameters. Eighteen karate professionals, 15 wrestlers, and 14 kickboxers participated in the study. Hematological, iron-related, oxidative stress, and immunological parameters were measured at the beginning of a precompetitive period. The general linear model showed significant differences between the karate professionals, wrestlers, and kickboxers with respect to their hematological and iron status parameters (Wilks' Lambda = 0.270, F = 2.186, p  lt  0.05) and oxidative stress status (Wilks' Lambda = 0.529, F = 1.940, p  lt  0.05). The immature reticulocyte fraction was significantly higher in wrestlers (0.30 +/- 0.03) compared with kickboxers (0.24 +/- 0.04; p  lt  0.05) and karate professionals (0.26 +/- 0.04; p  lt  0.05). Low hemoglobin density was significantly lower in wrestlers and kickboxers (p  lt  0.05) compared with karate professionals (karate: 3.51 +/- 1.19, wrestlers: 1.95 +/- 1.10, and kickboxers: 1.77 +/- 0.76). Significant differences were observed between the karate professionals and wrestlers with respect to their pro-oxidant-antioxidant balance (437 +/- 103 vs. 323 +/- 148, p  lt  0.05) and superoxide-dismutase activity (SOD) (73 +/- 37 vs. 103 +/- 30, p  lt  0.05). All the measured parameters (with the exception of SOD activity) fell within their physiological ranges, indicating that the study participants represented a young and healthy male population. Hematological parameters differed between kickboxers and karate professionals. The low pro-oxidant-antioxidant balance and high SOD activity in wrestlers could be associated with the long-term impact of wrestling as a type of strenuous exercise.",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Journal of strength and conditioning research",
title = "Hematological, oxidative stress, and immune status profiling in elite combat sport athletes",
volume = "27",
number = "12",
pages = "3506-3514",
doi = "10.1519/JSC.0b013e31828ddeea"
}

Dopsaj, V., Martinović, J., Dopsaj, M., Kasum, G., Kotur-Stevuljević, J.,& Koropanovski, N.. (2013). Hematological, oxidative stress, and immune status profiling in elite combat sport athletes. in Journal of strength and conditioning research
Lippincott Williams & Wilkins, Philadelphia., 27(12), 3506-3514.
https://doi.org/10.1519/JSC.0b013e31828ddeea

Dopsaj V, Martinović J, Dopsaj M, Kasum G, Kotur-Stevuljević J, Koropanovski N. Hematological, oxidative stress, and immune status profiling in elite combat sport athletes. in Journal of strength and conditioning research. 2013;27(12):3506-3514.
doi:10.1519/JSC.0b013e31828ddeea .

Dopsaj, Violeta, Martinović, Jelena, Dopsaj, Milivoj, Kasum, Goran, Kotur-Stevuljević, Jelena, Koropanovski, Nenad, "Hematological, oxidative stress, and immune status profiling in elite combat sport athletes" in Journal of strength and conditioning research, 27, no. 12 (2013):3506-3514,
https://doi.org/10.1519/JSC.0b013e31828ddeea . .