Supercritical carbon dioxide (scCO(2)) technology was used for preparation of functional pH sensitive chitosan-based aerogels characterized with micron size pores and their impregnation with thymol as a natural bioactive substance. Hydrogels based on chitosan, itaconic and methacrylic acids were transformed to alcogels and dried in the air or with scCO(2) to obtain xero- and aerogels, respectively. Applying 10 min of static and 120 min of dynamic scCO(2) drying at 11 MPa and 45 degrees C followed with the decompression at a rate of 1 MPa/min yielded an advantageous aerogel with favorable swelling kinetics and elasticity, compared to the xerogel and aerogels obtained at other decompression rates and drying times. This aerogel was successfully loaded with thymol (up to 4.6 wt.%) using supercritical scCO(2) at 10 MPa and 35 degrees C. In vitro studies of swelling in PBS at 37 degrees C indicated a great potential of the obtained stimuli-responsive chitosan gels for topical administration ...of thymol known for antimicrobial, antioxidant and anti-inflammatory activities. POLYM. ENG. SCI., 58:2192-2199, 2018. (c) 2018 Society of Plastics Engineers
Source:
Polymer engineering and science, 2018, 58, 12, 2192-2199
TY - JOUR
AU - Terzić, Ivan
AU - Ivanović, Jasna
AU - Zizović, Irena
AU - Lucić, Skorić, Marija
AU - Milosavljević, Nedeljko
AU - Milašinović, Nikola
AU - Kalagasidis-Krušić, Melina T.
PY - 2018
UR - http://jakov.kpu.edu.rs/handle/123456789/833
AB - Supercritical carbon dioxide (scCO(2)) technology was used for preparation of functional pH sensitive chitosan-based aerogels characterized with micron size pores and their impregnation with thymol as a natural bioactive substance. Hydrogels based on chitosan, itaconic and methacrylic acids were transformed to alcogels and dried in the air or with scCO(2) to obtain xero- and aerogels, respectively. Applying 10 min of static and 120 min of dynamic scCO(2) drying at 11 MPa and 45 degrees C followed with the decompression at a rate of 1 MPa/min yielded an advantageous aerogel with favorable swelling kinetics and elasticity, compared to the xerogel and aerogels obtained at other decompression rates and drying times. This aerogel was successfully loaded with thymol (up to 4.6 wt.%) using supercritical scCO(2) at 10 MPa and 35 degrees C. In vitro studies of swelling in PBS at 37 degrees C indicated a great potential of the obtained stimuli-responsive chitosan gels for topical administration of thymol known for antimicrobial, antioxidant and anti-inflammatory activities. POLYM. ENG. SCI., 58:2192-2199, 2018. (c) 2018 Society of Plastics Engineers
PB - Wiley, Hoboken
T2 - Polymer engineering and science
T1 - A novel chitosan gels: Supercritical CO2 drying and impregnation with thymol
VL - 58
IS - 12
SP - 2192
EP - 2199
DO - 10.1002/pen.24834
ER -
@article{
author = "Terzić, Ivan and Ivanović, Jasna and Zizović, Irena and Lucić, Skorić, Marija and Milosavljević, Nedeljko and Milašinović, Nikola and Kalagasidis-Krušić, Melina T.",
year = "2018",
abstract = "Supercritical carbon dioxide (scCO(2)) technology was used for preparation of functional pH sensitive chitosan-based aerogels characterized with micron size pores and their impregnation with thymol as a natural bioactive substance. Hydrogels based on chitosan, itaconic and methacrylic acids were transformed to alcogels and dried in the air or with scCO(2) to obtain xero- and aerogels, respectively. Applying 10 min of static and 120 min of dynamic scCO(2) drying at 11 MPa and 45 degrees C followed with the decompression at a rate of 1 MPa/min yielded an advantageous aerogel with favorable swelling kinetics and elasticity, compared to the xerogel and aerogels obtained at other decompression rates and drying times. This aerogel was successfully loaded with thymol (up to 4.6 wt.%) using supercritical scCO(2) at 10 MPa and 35 degrees C. In vitro studies of swelling in PBS at 37 degrees C indicated a great potential of the obtained stimuli-responsive chitosan gels for topical administration of thymol known for antimicrobial, antioxidant and anti-inflammatory activities. POLYM. ENG. SCI., 58:2192-2199, 2018. (c) 2018 Society of Plastics Engineers",
publisher = "Wiley, Hoboken",
journal = "Polymer engineering and science",
title = "A novel chitosan gels: Supercritical CO2 drying and impregnation with thymol",
volume = "58",
number = "12",
pages = "2192-2199",
doi = "10.1002/pen.24834"
}
Terzić, I., Ivanović, J., Zizović, I., Lucić, S. M., Milosavljević, N., Milašinović, N.,& Kalagasidis-Krušić, M. T.. (2018). A novel chitosan gels: Supercritical CO2 drying and impregnation with thymol. in Polymer engineering and science
Wiley, Hoboken., 58(12), 2192-2199.
https://doi.org/10.1002/pen.24834
Terzić I, Ivanović J, Zizović I, Lucić SM, Milosavljević N, Milašinović N, Kalagasidis-Krušić MT. A novel chitosan gels: Supercritical CO2 drying and impregnation with thymol. in Polymer engineering and science. 2018;58(12):2192-2199.
doi:10.1002/pen.24834 .
Terzić, Ivan, Ivanović, Jasna, Zizović, Irena, Lucić, Skorić, Marija, Milosavljević, Nedeljko, Milašinović, Nikola, Kalagasidis-Krušić, Melina T., "A novel chitosan gels: Supercritical CO2 drying and impregnation with thymol" in Polymer engineering and science, 58, no. 12 (2018):2192-2199,
https://doi.org/10.1002/pen.24834 . .
