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dc.creatorPejić, Marija
dc.creatorJanković, Milica
dc.creatorĐordjević, Snežana
dc.creatorKoturević, Biljana
dc.date.accessioned2022-05-24T12:43:04Z
dc.date.available2022-05-24T12:43:04Z
dc.date.issued2020
dc.identifier.urihttp://jakov.kpu.edu.rs/handle/123456789/1341
dc.description.abstractAtropine from herbs has been used in traditional medicine over centuries, mainly because of its hallucinogenic properties. When administrated orally through abusing of Datura stramonium (DS) seeds, atropine is quickly absorbed causing dilatation of the pupil, tachycardia, hyperthermia, dizziness, nausea, extreme confusion, deliriant hallucinations and in some cases death. Knowing that Datura stramonium is one of the “legal high” plants with a high risk of toxicity for humans and animals, forensic analysis of such a material is of high importance. This work aimed at developing a fast and simple method for extraction and determination of the atropine content as the main alkaloid in DS seeds. Optimization of parameters for conventional heated solid-liquid extraction of atropine from DS seeds were obtained by varying the particle size (8.6 mm-1.7 mm), temperature (40°C-60 °C), and ethanol concentration (48.0-96.0 % v/v). The extracts were analyzed by Acquity UPLC HSS C18 1.8 μm column with mobile phase acetonitrile and formate buffer pH 3.6 (75:25) and flow rate of 0.4 mL/min. Quantitation was done in MRM mode using m/z 290→ 124 and 290→ 93 transitions.sr
dc.language.isoensr
dc.publisherBelgrade : University of Criminal Investigation and Police Studiessr
dc.rightsopenAccesssr
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceThematic conference proceedings of international significance [Elektronski izvor] / International Scientific Conference "Archibald Reiss Days", Belgrade, 18-19 November 2020.sr
dc.subjectDatura stramoniumsr
dc.subjectdrugsr
dc.subjectatropinesr
dc.subjectextractionsr
dc.subjectMS-MS spectrometrysr
dc.titleExtraction and identification of atropine from “legal high” plant speciessr
dc.typeconferenceObjectsr
dc.rights.licenseBYsr
dc.citation.spage713
dc.citation.epage720
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_jakov_1341
dc.identifier.fulltexthttp://jakov.kpu.edu.rs/bitstream/id/5844/BK.pdf
dc.type.versionpublishedVersionsr


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