TY  - JOUR
AU  - Mijanović, Olja
AU  - Branković, Ana
AU  - Panin,  Alexander N.
AU  - Savchuk, Solomiia
AU  - Timashev, Peter
AU  - Ulasov, llya
AU  - Lesniak, Maciej S.
PY  - 2019
UR  - http://jakov.kpu.edu.rs/handle/123456789/891
AB  - Clinical, biochemical and molecular biology studies have identified lysosome-encapsulated cellular proteases as critical risk factors for cancer progression. Cathepsins represent a group of such proteases aimed at maintenance of cellular homeostasis. Nevertheless, recent reports suggest that Cathepsin B executes other cellular programs such as controlling tumor growth, migration, invasion, angiogenesis, and metastases development. In fact, elevated levels of Cathepsins are found under different pathological conditions including inflammation, infection, neurodegenerative disease, and cancer. Furthermore, the discovery of Cathepsin B secretion and function as an extracellular matrix protein has broadened our appreciation for the impact of Cathepsin B on cancer progression. Underneath a façade of an intracellular protease with limited therapeutic potential hides a central role of cathepsins in extracellular functions. Moreover, this role is incredibly diverse from one condition to the next – from driving caspase-dependent apoptosis to facilitating tumor neovascularization and metastasis. Here we discuss the role of Cathepsin B in the oncogenic process and perspective the use of Cathepsin B for diagnostic and therapeutic applications.
PB  - Elsevier
T2  - Cancer Letters
T1  - Cathepsin B: A sellsword of cancer progression
VL  - 449
SP  - 207
EP  - 214
DO  - 10.1016/j.canlet.2019.02.035
ER  - 

@article{
author = "Mijanović, Olja and Branković, Ana and Panin,  Alexander N. and Savchuk, Solomiia and Timashev, Peter and Ulasov, llya and Lesniak, Maciej S.",
year = "2019",
abstract = "Clinical, biochemical and molecular biology studies have identified lysosome-encapsulated cellular proteases as critical risk factors for cancer progression. Cathepsins represent a group of such proteases aimed at maintenance of cellular homeostasis. Nevertheless, recent reports suggest that Cathepsin B executes other cellular programs such as controlling tumor growth, migration, invasion, angiogenesis, and metastases development. In fact, elevated levels of Cathepsins are found under different pathological conditions including inflammation, infection, neurodegenerative disease, and cancer. Furthermore, the discovery of Cathepsin B secretion and function as an extracellular matrix protein has broadened our appreciation for the impact of Cathepsin B on cancer progression. Underneath a façade of an intracellular protease with limited therapeutic potential hides a central role of cathepsins in extracellular functions. Moreover, this role is incredibly diverse from one condition to the next – from driving caspase-dependent apoptosis to facilitating tumor neovascularization and metastasis. Here we discuss the role of Cathepsin B in the oncogenic process and perspective the use of Cathepsin B for diagnostic and therapeutic applications.",
publisher = "Elsevier",
journal = "Cancer Letters",
title = "Cathepsin B: A sellsword of cancer progression",
volume = "449",
pages = "207-214",
doi = "10.1016/j.canlet.2019.02.035"
}

Mijanović, O., Branković, A., Panin, A. N., Savchuk, S., Timashev, P., Ulasov, l.,& Lesniak, M. S.. (2019). Cathepsin B: A sellsword of cancer progression. in Cancer Letters
Elsevier., 449, 207-214.
https://doi.org/10.1016/j.canlet.2019.02.035

Mijanović O, Branković A, Panin AN, Savchuk S, Timashev P, Ulasov L, Lesniak MS. Cathepsin B: A sellsword of cancer progression. in Cancer Letters. 2019;449:207-214.
doi:10.1016/j.canlet.2019.02.035 .

Mijanović, Olja, Branković, Ana, Panin,  Alexander N., Savchuk, Solomiia, Timashev, Peter, Ulasov, llya, Lesniak, Maciej S., "Cathepsin B: A sellsword of cancer progression" in Cancer Letters, 449 (2019):207-214,
https://doi.org/10.1016/j.canlet.2019.02.035 . .

TY  - JOUR
AU  - Mijanović, Olja
AU  - Branković, Ana
AU  - Panin,  Alexander N.
AU  - Savchuk, Solomiia
AU  - Timashev, Peter
AU  - Ulasov, llya
AU  - Lesniak, Maciej S.
PY  - 2019
UR  - http://jakov.kpu.edu.rs/handle/123456789/871
AB  - Clinical, biochemical and molecular biology studies have identified lysosome-encapsulated cellular proteases as critical risk factors for cancer progression. Cathepsins represent a group of such proteases aimed at maintenance of cellular homeostasis. Nevertheless, recent reports suggest that Cathepsin B executes other cellular programs such as controlling tumor growth, migration, invasion, angiogenesis, and metastases development. In fact, elevated levels of Cathepsins are found under different pathological conditions including inflammation, infection, neurodegenerative disease, and cancer. Furthermore, the discovery of Cathepsin B secretion and function as an extracellular matrix protein has broadened our appreciation for the impact of Cathepsin B on cancer progression. Underneath a façade of an intracellular protease with limited therapeutic potential hides a central role of cathepsins in extracellular functions. Moreover, this role is incredibly diverse from one condition to the next – from driving caspase-dependent apoptosis to facilitating tumor neovascularization and metastasis. Here we discuss the role of Cathepsin B in the oncogenic process and perspective the use of Cathepsin B for diagnostic and therapeutic applications.
T2  - Cancer Letters
T1  - Cathepsin B: A sellsword of cancer progression
VL  - 449
SP  - 207
EP  - 214
DO  - 10.1016/j.canlet.2019.02.035
ER  - 

@article{
author = "Mijanović, Olja and Branković, Ana and Panin,  Alexander N. and Savchuk, Solomiia and Timashev, Peter and Ulasov, llya and Lesniak, Maciej S.",
year = "2019",
abstract = "Clinical, biochemical and molecular biology studies have identified lysosome-encapsulated cellular proteases as critical risk factors for cancer progression. Cathepsins represent a group of such proteases aimed at maintenance of cellular homeostasis. Nevertheless, recent reports suggest that Cathepsin B executes other cellular programs such as controlling tumor growth, migration, invasion, angiogenesis, and metastases development. In fact, elevated levels of Cathepsins are found under different pathological conditions including inflammation, infection, neurodegenerative disease, and cancer. Furthermore, the discovery of Cathepsin B secretion and function as an extracellular matrix protein has broadened our appreciation for the impact of Cathepsin B on cancer progression. Underneath a façade of an intracellular protease with limited therapeutic potential hides a central role of cathepsins in extracellular functions. Moreover, this role is incredibly diverse from one condition to the next – from driving caspase-dependent apoptosis to facilitating tumor neovascularization and metastasis. Here we discuss the role of Cathepsin B in the oncogenic process and perspective the use of Cathepsin B for diagnostic and therapeutic applications.",
journal = "Cancer Letters",
title = "Cathepsin B: A sellsword of cancer progression",
volume = "449",
pages = "207-214",
doi = "10.1016/j.canlet.2019.02.035"
}

Mijanović, O., Branković, A., Panin, A. N., Savchuk, S., Timashev, P., Ulasov, l.,& Lesniak, M. S.. (2019). Cathepsin B: A sellsword of cancer progression. in Cancer Letters, 449, 207-214.
https://doi.org/10.1016/j.canlet.2019.02.035

Mijanović O, Branković A, Panin AN, Savchuk S, Timashev P, Ulasov L, Lesniak MS. Cathepsin B: A sellsword of cancer progression. in Cancer Letters. 2019;449:207-214.
doi:10.1016/j.canlet.2019.02.035 .

Mijanović, Olja, Branković, Ana, Panin,  Alexander N., Savchuk, Solomiia, Timashev, Peter, Ulasov, llya, Lesniak, Maciej S., "Cathepsin B: A sellsword of cancer progression" in Cancer Letters, 449 (2019):207-214,
https://doi.org/10.1016/j.canlet.2019.02.035 . .