Приказ основних података о документу
Encapsulation of alpha-lipoic acid into chitosan and alginate/gelatin hydrogel microparticles and its in vitro antioxidant activity
dc.creator | Vidović, Bojana | |
dc.creator | Milašinović, Nikola | |
dc.creator | Kotur-Stevuljević, Jelena | |
dc.creator | Dilber, Sanda P. | |
dc.creator | Kalagasidis-Krušić, Melina T. | |
dc.creator | Đoržević, Brižita | |
dc.creator | Knežević-Jugović, Zorica | |
dc.date.accessioned | 2019-03-21T16:08:42Z | |
dc.date.available | 2019-03-21T16:08:42Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 0367-598X | |
dc.identifier.uri | http://jakov.kpu.edu.rs/handle/123456789/732 | |
dc.description.abstract | Alpha-lipoic acid is an organosulphur compound well-known for its therapeutic potential and antioxidant properties. However, the effective use of alpha-lipoic acid depends on biological plasma half-life and its preserving stability, which could be improved by encapsulation. In this study, alpha-lipoic acid was incorporated into chitosan microparticles obtained by reverse emulsion crosslinking technique, as well as into microparticles of alginate/gelatin crosslinked with zinc ions. Encapsulation of alpha-lipoic acid in both cases was carried out by swelling of synthesized dried microparticles by their dipping in a solution of the active substance under strictly controlled conditions. Encapsulation efficiency of alpha-lipoic acid obtained in this study was up to 53.9%. The structural interaction of alpha-lipoic acid with the carriers was revealed by Fourier transform infrared spectroscopy. In vitro released studies showed that controlled release of alpha-lipoic acid was achieved through its encapsulation into chitosan microparticles. The results of in vitro antioxidative activity assays of released alpha-lipoic acid indicated that antioxidant activity was preserved at a satisfactory level. These obtained results suggested that chitosan microparticles could be suitable for modeling the controlled release of alpha-lipoic acid. | en |
dc.publisher | Association of Chemical Engineers of Serbia | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46010/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46001/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Hemijska industrija | |
dc.subject | alpha-lipoic acid | en |
dc.subject | microparticles | en |
dc.subject | chitosan | en |
dc.subject | sodium alginate/gelatin | en |
dc.subject | antioxidant activity | en |
dc.title | Encapsulation of alpha-lipoic acid into chitosan and alginate/gelatin hydrogel microparticles and its in vitro antioxidant activity | en |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dcterms.abstract | Милашиновић, Никола; Видовић, Бојана; Котур-Стевуљевић, Јелена; Ђоржевић, Брижита; Калагасидис-Крушић, Мелина Т.; Кнежевић-Југовић, Зорица; Дилбер, Санда П.; | |
dc.citation.volume | 70 | |
dc.citation.issue | 1 | |
dc.citation.spage | 49 | |
dc.citation.epage | 58 | |
dc.citation.other | 70(1): 49-58 | |
dc.citation.rank | M23 | |
dc.identifier.doi | 10.2298/HEMIND141119010V | |
dc.identifier.fulltext | http://jakov.kpu.edu.rs/bitstream/id/2812/730.pdf | |
dc.identifier.scopus | 2-s2.0-84960341974 | |
dc.identifier.wos | 000372733800006 | |
dc.type.version | publishedVersion |