Influence of Vitamin C Supplementation on Oxidative Stress and Neutrophil Inflammatory Response in Acute and Regular Exercise
2015
Authors
Popović, Ljiljana M.Mitić, Nebojša R.
Mirić, Dijana
Bisevac, Boban
Mirić, Mirjana
Popović, Brankica
Article (Published version)
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Exercise induces a multitude of physiological and biochemical changes in blood affecting its redox status. Tissue damage resulting fromexercise induces activation of inflammatory cells followed by the increased activity ofmyeloperoxidase (MPO) in circulation. Vitamin C readily scavenges free radicals and may thereby prevent oxidative damage of important biological macromolecules. The aimof this study was to examine the effect of vitamin C supplementation on oxidative stress and neutrophil inflammatory response induced by acute and regular exercise. Experiment was conducted on acute exercise group (performing Bruce Treadmill Protocol (BTP)) and regular training group. Markers of lipid peroxidation, malondialdehyde (MDA), MPO activity, and vitamin C status were estimated at rest and after BTP (acute exercise group) and before and after vitamin C supplementation in both groups. Our results showed increased postexercise Asc in serum independently of vitamin supplementation. They also showe...d that vitamin C can significantly decrease postexercise MDA level in both experimental groups. Increased postexercise MPO activity has been found in both groups and was not affected by vitamin C supplementation. We concluded that vitamin C supplementation can suppress lipid peroxidation process during exercise but cannot affect neutrophil inflammatory response in either exercise group.
Source:
Oxidative medicine and cellular longevity, 2015Publisher:
- Hindawi Limited
Funding / projects:
- New Information Technologies for Analytical Decision Making Based on Experiment Observation and their Application in Biological, Economic and Sociological Systems (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-44007)
DOI: 10.1155/2015/295497
ISSN: 1942-0900
WoS: 000351087200001
Scopus: 2-s2.0-84924599428
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JakovTY - JOUR AU - Popović, Ljiljana M. AU - Mitić, Nebojša R. AU - Mirić, Dijana AU - Bisevac, Boban AU - Mirić, Mirjana AU - Popović, Brankica PY - 2015 UR - http://jakov.kpu.edu.rs/handle/123456789/666 AB - Exercise induces a multitude of physiological and biochemical changes in blood affecting its redox status. Tissue damage resulting fromexercise induces activation of inflammatory cells followed by the increased activity ofmyeloperoxidase (MPO) in circulation. Vitamin C readily scavenges free radicals and may thereby prevent oxidative damage of important biological macromolecules. The aimof this study was to examine the effect of vitamin C supplementation on oxidative stress and neutrophil inflammatory response induced by acute and regular exercise. Experiment was conducted on acute exercise group (performing Bruce Treadmill Protocol (BTP)) and regular training group. Markers of lipid peroxidation, malondialdehyde (MDA), MPO activity, and vitamin C status were estimated at rest and after BTP (acute exercise group) and before and after vitamin C supplementation in both groups. Our results showed increased postexercise Asc in serum independently of vitamin supplementation. They also showed that vitamin C can significantly decrease postexercise MDA level in both experimental groups. Increased postexercise MPO activity has been found in both groups and was not affected by vitamin C supplementation. We concluded that vitamin C supplementation can suppress lipid peroxidation process during exercise but cannot affect neutrophil inflammatory response in either exercise group. PB - Hindawi Limited T2 - Oxidative medicine and cellular longevity T1 - Influence of Vitamin C Supplementation on Oxidative Stress and Neutrophil Inflammatory Response in Acute and Regular Exercise DO - 10.1155/2015/295497 ER -
@article{ author = "Popović, Ljiljana M. and Mitić, Nebojša R. and Mirić, Dijana and Bisevac, Boban and Mirić, Mirjana and Popović, Brankica", year = "2015", abstract = "Exercise induces a multitude of physiological and biochemical changes in blood affecting its redox status. Tissue damage resulting fromexercise induces activation of inflammatory cells followed by the increased activity ofmyeloperoxidase (MPO) in circulation. Vitamin C readily scavenges free radicals and may thereby prevent oxidative damage of important biological macromolecules. The aimof this study was to examine the effect of vitamin C supplementation on oxidative stress and neutrophil inflammatory response induced by acute and regular exercise. Experiment was conducted on acute exercise group (performing Bruce Treadmill Protocol (BTP)) and regular training group. Markers of lipid peroxidation, malondialdehyde (MDA), MPO activity, and vitamin C status were estimated at rest and after BTP (acute exercise group) and before and after vitamin C supplementation in both groups. Our results showed increased postexercise Asc in serum independently of vitamin supplementation. They also showed that vitamin C can significantly decrease postexercise MDA level in both experimental groups. Increased postexercise MPO activity has been found in both groups and was not affected by vitamin C supplementation. We concluded that vitamin C supplementation can suppress lipid peroxidation process during exercise but cannot affect neutrophil inflammatory response in either exercise group.", publisher = "Hindawi Limited", journal = "Oxidative medicine and cellular longevity", title = "Influence of Vitamin C Supplementation on Oxidative Stress and Neutrophil Inflammatory Response in Acute and Regular Exercise", doi = "10.1155/2015/295497" }
Popović, L. M., Mitić, N. R., Mirić, D., Bisevac, B., Mirić, M.,& Popović, B.. (2015). Influence of Vitamin C Supplementation on Oxidative Stress and Neutrophil Inflammatory Response in Acute and Regular Exercise. in Oxidative medicine and cellular longevity Hindawi Limited.. https://doi.org/10.1155/2015/295497
Popović LM, Mitić NR, Mirić D, Bisevac B, Mirić M, Popović B. Influence of Vitamin C Supplementation on Oxidative Stress and Neutrophil Inflammatory Response in Acute and Regular Exercise. in Oxidative medicine and cellular longevity. 2015;. doi:10.1155/2015/295497 .
Popović, Ljiljana M., Mitić, Nebojša R., Mirić, Dijana, Bisevac, Boban, Mirić, Mirjana, Popović, Brankica, "Influence of Vitamin C Supplementation on Oxidative Stress and Neutrophil Inflammatory Response in Acute and Regular Exercise" in Oxidative medicine and cellular longevity (2015), https://doi.org/10.1155/2015/295497 . .