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dc.creatorVidović, Bojana
dc.creatorMilašinović, Nikola
dc.creatorKotur-Stevuljević, Jelena
dc.creatorDilber, Sanda P.
dc.creatorKalagasidis-Krušić, Melina T.
dc.creatorĐoržević, Brižita
dc.creatorKnežević-Jugović, Zorica
dc.date.accessioned2019-03-21T16:08:42Z
dc.date.available2019-03-21T16:08:42Z
dc.date.issued2016
dc.identifier.issn0367-598X
dc.identifier.urihttp://jakov.kpu.edu.rs/handle/123456789/732
dc.description.abstractAlpha-lipoic acid is an organosulphur compound well-known for its therapeutic potential and antioxidant properties. However, the effective use of alpha-lipoic acid depends on biological plasma half-life and its preserving stability, which could be improved by encapsulation. In this study, alpha-lipoic acid was incorporated into chitosan microparticles obtained by reverse emulsion crosslinking technique, as well as into microparticles of alginate/gelatin crosslinked with zinc ions. Encapsulation of alpha-lipoic acid in both cases was carried out by swelling of synthesized dried microparticles by their dipping in a solution of the active substance under strictly controlled conditions. Encapsulation efficiency of alpha-lipoic acid obtained in this study was up to 53.9%. The structural interaction of alpha-lipoic acid with the carriers was revealed by Fourier transform infrared spectroscopy. In vitro released studies showed that controlled release of alpha-lipoic acid was achieved through its encapsulation into chitosan microparticles. The results of in vitro antioxidative activity assays of released alpha-lipoic acid indicated that antioxidant activity was preserved at a satisfactory level. These obtained results suggested that chitosan microparticles could be suitable for modeling the controlled release of alpha-lipoic acid.en
dc.publisherAssociation of Chemical Engineers of Serbia
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46010/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46001/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceHemijska industrija
dc.subjectalpha-lipoic aciden
dc.subjectmicroparticlesen
dc.subjectchitosanen
dc.subjectsodium alginate/gelatinen
dc.subjectantioxidant activityen
dc.titleEncapsulation of alpha-lipoic acid into chitosan and alginate/gelatin hydrogel microparticles and its in vitro antioxidant activityen
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractМилашиновић, Никола; Видовић, Бојана; Котур-Стевуљевић, Јелена; Ђоржевић, Брижита; Калагасидис-Крушић, Мелина Т.; Кнежевић-Југовић, Зорица; Дилбер, Санда П.;
dc.citation.volume70
dc.citation.issue1
dc.citation.spage49
dc.citation.epage58
dc.citation.other70(1): 49-58
dc.citation.rankM23
dc.identifier.doi10.2298/HEMIND141119010V
dc.identifier.fulltexthttp://jakov.kpu.edu.rs/bitstream/id/2812/730.pdf
dc.identifier.scopus2-s2.0-84960341974
dc.identifier.wos000372733800006
dc.type.versionpublishedVersion


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