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Influence of Vitamin C Supplementation on Oxidative Stress and Neutrophil Inflammatory Response in Acute and Regular Exercise

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2015
664.pdf (1.413Mb)
Authors
Popović, Ljiljana M.
Mitić, Nebojša R.
Mirić, Dijana
Bisevac, Boban
Mirić, Mirjana
Popović, Brankica
Article (Published version)
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Abstract
Exercise induces a multitude of physiological and biochemical changes in blood affecting its redox status. Tissue damage resulting fromexercise induces activation of inflammatory cells followed by the increased activity ofmyeloperoxidase (MPO) in circulation. Vitamin C readily scavenges free radicals and may thereby prevent oxidative damage of important biological macromolecules. The aimof this study was to examine the effect of vitamin C supplementation on oxidative stress and neutrophil inflammatory response induced by acute and regular exercise. Experiment was conducted on acute exercise group (performing Bruce Treadmill Protocol (BTP)) and regular training group. Markers of lipid peroxidation, malondialdehyde (MDA), MPO activity, and vitamin C status were estimated at rest and after BTP (acute exercise group) and before and after vitamin C supplementation in both groups. Our results showed increased postexercise Asc in serum independently of vitamin supplementation. They also showe...d that vitamin C can significantly decrease postexercise MDA level in both experimental groups. Increased postexercise MPO activity has been found in both groups and was not affected by vitamin C supplementation. We concluded that vitamin C supplementation can suppress lipid peroxidation process during exercise but cannot affect neutrophil inflammatory response in either exercise group.

Source:
Oxidative medicine and cellular longevity, 2015
Publisher:
  • Hindawi Limited
Funding / projects:
  • New Information Technologies for Analytical Decision Making Based on Experiment Observation and their Application in Biological, Economic and Sociological Systems (RS-44007)

DOI: 10.1155/2015/295497

ISSN: 1942-0900

WoS: 000351087200001

Scopus: 2-s2.0-84924599428
[ Google Scholar ]
21
16
URI
http://jakov.kpu.edu.rs/handle/123456789/666
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
Jakov
TY  - JOUR
AU  - Popović, Ljiljana M.
AU  - Mitić, Nebojša R.
AU  - Mirić, Dijana
AU  - Bisevac, Boban
AU  - Mirić, Mirjana
AU  - Popović, Brankica
PY  - 2015
UR  - http://jakov.kpu.edu.rs/handle/123456789/666
AB  - Exercise induces a multitude of physiological and biochemical changes in blood affecting its redox status. Tissue damage resulting fromexercise induces activation of inflammatory cells followed by the increased activity ofmyeloperoxidase (MPO) in circulation. Vitamin C readily scavenges free radicals and may thereby prevent oxidative damage of important biological macromolecules. The aimof this study was to examine the effect of vitamin C supplementation on oxidative stress and neutrophil inflammatory response induced by acute and regular exercise. Experiment was conducted on acute exercise group (performing Bruce Treadmill Protocol (BTP)) and regular training group. Markers of lipid peroxidation, malondialdehyde (MDA), MPO activity, and vitamin C status were estimated at rest and after BTP (acute exercise group) and before and after vitamin C supplementation in both groups. Our results showed increased postexercise Asc in serum independently of vitamin supplementation. They also showed that vitamin C can significantly decrease postexercise MDA level in both experimental groups. Increased postexercise MPO activity has been found in both groups and was not affected by vitamin C supplementation. We concluded that vitamin C supplementation can suppress lipid peroxidation process during exercise but cannot affect neutrophil inflammatory response in either exercise group.
PB  - Hindawi Limited
T2  - Oxidative medicine and cellular longevity
T1  - Influence of Vitamin C Supplementation on Oxidative Stress and Neutrophil Inflammatory Response in Acute and Regular Exercise
DO  - 10.1155/2015/295497
UR  - conv_1133
ER  - 
@article{
author = "Popović, Ljiljana M. and Mitić, Nebojša R. and Mirić, Dijana and Bisevac, Boban and Mirić, Mirjana and Popović, Brankica",
year = "2015",
abstract = "Exercise induces a multitude of physiological and biochemical changes in blood affecting its redox status. Tissue damage resulting fromexercise induces activation of inflammatory cells followed by the increased activity ofmyeloperoxidase (MPO) in circulation. Vitamin C readily scavenges free radicals and may thereby prevent oxidative damage of important biological macromolecules. The aimof this study was to examine the effect of vitamin C supplementation on oxidative stress and neutrophil inflammatory response induced by acute and regular exercise. Experiment was conducted on acute exercise group (performing Bruce Treadmill Protocol (BTP)) and regular training group. Markers of lipid peroxidation, malondialdehyde (MDA), MPO activity, and vitamin C status were estimated at rest and after BTP (acute exercise group) and before and after vitamin C supplementation in both groups. Our results showed increased postexercise Asc in serum independently of vitamin supplementation. They also showed that vitamin C can significantly decrease postexercise MDA level in both experimental groups. Increased postexercise MPO activity has been found in both groups and was not affected by vitamin C supplementation. We concluded that vitamin C supplementation can suppress lipid peroxidation process during exercise but cannot affect neutrophil inflammatory response in either exercise group.",
publisher = "Hindawi Limited",
journal = "Oxidative medicine and cellular longevity",
title = "Influence of Vitamin C Supplementation on Oxidative Stress and Neutrophil Inflammatory Response in Acute and Regular Exercise",
doi = "10.1155/2015/295497",
url = "conv_1133"
}
Popović, L. M., Mitić, N. R., Mirić, D., Bisevac, B., Mirić, M.,& Popović, B.. (2015). Influence of Vitamin C Supplementation on Oxidative Stress and Neutrophil Inflammatory Response in Acute and Regular Exercise. in Oxidative medicine and cellular longevity
Hindawi Limited..
https://doi.org/10.1155/2015/295497
conv_1133
Popović LM, Mitić NR, Mirić D, Bisevac B, Mirić M, Popović B. Influence of Vitamin C Supplementation on Oxidative Stress and Neutrophil Inflammatory Response in Acute and Regular Exercise. in Oxidative medicine and cellular longevity. 2015;.
doi:10.1155/2015/295497
conv_1133 .
Popović, Ljiljana M., Mitić, Nebojša R., Mirić, Dijana, Bisevac, Boban, Mirić, Mirjana, Popović, Brankica, "Influence of Vitamin C Supplementation on Oxidative Stress and Neutrophil Inflammatory Response in Acute and Regular Exercise" in Oxidative medicine and cellular longevity (2015),
https://doi.org/10.1155/2015/295497 .,
conv_1133 .

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