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dc.creatorTrifković, Kata T.
dc.creatorMilašinović, Nikola
dc.creatorĐorđević, Verica
dc.creatorZdunić, Gordana
dc.creatorKalagasidis-Krušić, Melina T.
dc.creatorKnežević-Jugović, Zorica
dc.creatorSavikin, Katarina
dc.creatorNedović, Viktor
dc.creatorBugarski, Branko M.
dc.date.accessioned2019-03-21T16:05:59Z
dc.date.available2019-03-21T16:05:59Z
dc.date.issued2015
dc.identifier.issn0885-3282
dc.identifier.urihttp://jakov.kpu.edu.rs/handle/123456789/639
dc.description.abstractChitosan-glutaraldehyde microparticles were produced by emulsion crosslinking method to be used as drug delivery system for polyphenols from Thymus serpyllum L. aqueous extract. The effect of preparation conditions, chitosan concentration (1.5-3% w/v), and glutaraldehyde/chitosan (GA/Ch) mass ratio (0.15-1.20) on water and polyphenols transport properties was investigated. Swelling ratio of dry particles (68-230 mm) in water ranged from 280% to 530%, depending on the formulation. The decrease in swelling was observed with increased GA/Ch mass ratio (i.e. crosslinking degree) at the same chitosan concentration, or with increased chitosan concentration at the same GA/Ch mass ratio. The increase in GA/Ch mass ratio was also manifested by increased particle compactness i.e. decreased size and reduced surface roughness. The sorption capacity for polyphenols seems to be a complex interplay of swelling behaviour and interactions chitosan-glutaraldehyde-polyphenols identified by Fourier transmission infrared analysis. An increase in crystallinity of chitosan was observed upon crosslinking with glutaraldehyde and encapsulation of polyphenols, as observed by X-ray diffraction analysis. The results obtained from release kinetics of selected polyphenolic compounds (caffeic acid, rosmarinic acid, total flavonoids, and total phenol content) showed that polyphenols were released at a lower amount (2-4 times) in water, but more rapidly (45-120 min) in comparison with the release in gastric followed by intestinal simulated fluid (SGF-SIF) (120-240 min). The experimental results of the time-dependent swelling in water and polyphenols release in both, water and SGF-SIF, were analyzed with several mathematical models. The results depicted Fickian diffusion as the water transport mechanism. In the case of polyphenols, only empirical Weibull model could be suggested for describing release kinetics.en
dc.publisherSage Publications Ltd, London
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46010/RS//
dc.relationMinistry of the Interior of the Republic of Serbia [242/16-4-2014]
dc.rightsrestrictedAccess
dc.sourceJournal of biomaterials applications
dc.subjectChitosan microparticlesen
dc.subjectemulsion crosslinking methoden
dc.subjectwater sorptionen
dc.subjectpolyphenols releaseen
dc.subjectmathematical modelsen
dc.titleChitosan crosslinked microparticles with encapsulated polyphenols: Water sorption and release propertiesen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractТрифковић, Ката Т.; Здунић, Гордана; Савикин, Катарина; Недовић, Виктор; Бугарски, Бранко М.; Калагасидис-Крушић, Мелина Т.; Кнежевић-Југовић, Зорица; Милашиновић, Никола; Ђорђевић, Верица;
dc.citation.volume30
dc.citation.issue5
dc.citation.spage618
dc.citation.epage631
dc.citation.other30(5): 618-631
dc.citation.rankM22
dc.identifier.doi10.1177/0885328215598940
dc.identifier.rcubconv_1146
dc.identifier.scopus2-s2.0-84948977538
dc.identifier.wos000367743900012
dc.type.versionpublishedVersion


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